When people post images of the pale blue dot Earth and talk about perspective and insignificance, it’s still a sentimental response to the sight.
It’s no more reasonable than sentimental response to a spider bite or a fight with a friend. A wealth of feeling does not make sentiment more or less reasonable. It’s all human perspective.
We are both enormous and minuscule. No connotations necessary. We are big and we are small. We can only pretend to decide how much we matter, whether it is a lot or very little.